I may be retired from practice, but I still get new prescription drug alerts.

All-Day, All-Night
TUZISTRA XR IS THE ONLY 12-HOUR
CODEINE-BASED COUGH SYRUP1,2

Relieves coughs and helps avoid the doses,
wake-ups, and disruptions associated with
short-acting antitussives

Dosed at 10 mL every 12 hours, not to exceed
2 doses in 24 hours1

All commercially insured patients pay no more than
$25 for their prescriptions with a Co-pay Card*
*For more information, see Terms and Conditions of the
Pharmacy Savings Card Program at TuzistraXR.com.

Tuzistra XR (codeine polistirex and chlorpheniramine polistirex) Available for Patients Nationwide
Due to the current Codeine/Promethazine shortage, we are informing you that Tuzistra XR is
available nationwide as the only 12-hour codeine-based cough syrup. All commercially-insured
patients Pay No More Than $25. Savings cards available at tuzistraxr.com

Description
TUZISTRAXR (codeine polistirex and chlorpheniramine polistirex) contains 29.5 mg of codeine (equivalent to 40 mg codeine phosphate) and 5.6 mg of chlorpheniramine (equivalent to 8 mg chlorpheniramine maleate) per 10-mL dose.1
NDC number
69*654-48*0-01
Packaging
Packaging 16 fl oz (473 mL) bottle

TUZISTRA XR is a combination of codeine, an opiate agonist antitussive, and chlorpheniramine, a histamine-1 (H1) receptor antagonist indicated for relief of cough and symptoms associated with upper respiratory allergies or a common cold.
Limitation of Use: Not indicated for pediatric patients under 18 years of age.
IMPORTANT SAFETY INFORMATION
CONTRAINDICATIONS
•
Postoperative pain management of children undergoing tonsillectomy and/or adenoidectomy.
•
Patients with known hypersensitivity to codeine, chlorpheniramine, or any of the product components of TUZISTRA XR.
WARNING
DEATH RELATED TO ULTRA-RAPID METABOLISM OF CODEINE TO MORPHINE and RISKS FROM CONCOMITANT USE WITH BENZODIAZEPINES OR OTHER CNS DEPRESSANTS
Ultra-Rapid Metabolism
Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to a CYP2D6 polymorphism.
Concomitant Use with Benzodiazepines, CNS Depressants
Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Avoid use of opioid cough medications in patients taking benzodiazepines, other CNS depressants, or alcohol.

For emphasis, from above:

...indicated for relief of cough and symptoms associated with upper respiratory allergies or a common cold.

Got a cold, goy? I'll be sure you're going to get an opiate drug to get you started onto stronger stuff, heh-heh!!!

This can be easily strengthened into a serious drug of abuse. I shall not tell how. And, I can see a new "drank," worse than the old one!!!